Comedian, actor, and game show host Louie Anderson died on Friday, January 21, 2022, from diffuse large B cell lymphoma. He was 68 years old.

Anderson was born on March 24, 1953, and was raised in Saint Paul, Minnesota. His first major TV appearance as a stand-up comedian was on The Tonight Show with Johnny Carson in 1984. Since then, he has had several stand-up TV specials and done comedy tours. Two of his earliest film roles were in Ferris Bueller’s Day Off and in the Eddie Murphy comedy Coming to America.

His childhood in the Midwest was the subject of the animated series Life with Louie, which ran from 1994 to ’98. Anderson won two Daytime Emmys for his voiceover work on the show. Around this time, he also starred in the short-lived sitcom The Louie Show as a psychotherapist in Minnesota, but the show ended after just six episodes. In the late ‘90s to early 2000s, he hosted Family Feud, and did guest spots on Touched by an Angel, Ally McBeal, and Scrubs.

One of his most notable roles was in the dramedy Baskets with Zach Galifianakis, with the latter playing twins and Anderson as their mother Christine Baskets. Anderson won a Primetime Emmy Award for Supporting Actor in 2016, and was nominated in the next two years.

He was in the TV series Search Party, had a cameo in Coming 2 America, and his final role was in the TV show Twenties.