Science fiction is a fruitful genre for comics with zero limitations on what writers and artists can put on the page. They can be stories of aliens or amazing technology, a frightening look at experimentation or an optimistic view of the future. Sci-fi comics spread across other genres with the mad doctors in EC horror books or the Green Lantern Corps of DC.

Throughout The Overstreet Comic Book Price Guide’s history, Robert M. Overstreet has cataloged sci-fi comics to find which ones are most valuable in the secondary market. Below is the list of the Top 10 sci-fi comics reported in 2010’s Guide #40.

#1 – Mystery in Space #1 – $6,300
#2 – Strange Adventures #1 – $5,900
#3 – Showcase #17 – $5,000
#4 – Weird Science-Fantasy Annual (1952) – $4,200
#5 – Journey Into Unknown Worlds #36 – $4,000
#5 – Showcase #15 – $4,000
#7 – Fawcett Movie #15 – $3,800
#8 – Strange Adventures #9 – $3,550
#9 – Weird Fantasy #13 (#1) – $3,500
#9 – Weird Science #12 (#1) – $3,500